A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection

Mara Biasin; Manuela Sironi; Irma Saulle; Chiara Pontremoli; Micaela Garziano; Rachele Cagliani; Daria Trabattoni; Sergio Lo Caputo; Francesca Vichi; Francesco Mazzotta; Diego Forni; Stefania Riva; Wbeimar Aguilar-Jimenez; Samandhy Cedeño; Jorge Sanchez; Christian Brander; Wildeman Zapata; Maria Teresa Rugeles; Mario Clerici

doi:10.1016/j.micinf.2016.09.005

A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection

Mara Biasin, Manuela Sironi, Irma Saulle, Chiara Pontremoli, Micaela Garziano, Rachele Cagliani, Daria Trabattoni, Sergio Lo Caputo, Francesca Vichi, Francesco Mazzotta, Diego Forni, Stefania Riva, Wbeimar Aguilar-Jimenez, Samandhy Cedeño, Jorge Sanchez, Christian Brander, Wildeman Zapata, Maria Teresa Rugeles, Mario Clerici

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© 2016 Institut Pasteur We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a p value of 0.005. In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.

Idioma original	Anglès
Pàgines (de-a)	69-74
Revista	Microbes and Infection
Volum	19
Número	1
DOIs	https://doi.org/10.1016/j.micinf.2016.09.005
Estat de la publicació	Publicada - 1 de gen. 2017

SDG de les Nacions Unides

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10.1016/j.micinf.2016.09.005

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Biasin, M., Sironi, M., Saulle, I., Pontremoli, C., Garziano, M., Cagliani, R., Trabattoni, D., Lo Caputo, S., Vichi, F., Mazzotta, F., Forni, D., Riva, S., Aguilar-Jimenez, W., Cedeño, S., Sanchez, J., Brander, C., Zapata, W., Rugeles, M. T., & Clerici, M. (2017). A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection. Microbes and Infection, 19(1), 69-74. https://doi.org/10.1016/j.micinf.2016.09.005

@article{5b64209b6d9d4ddea801e946e427946f,

title = "A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection",

abstract = "{\textcopyright} 2016 Institut Pasteur We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a p value of 0.005. In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.",

keywords = "HESN, HIV, Polymorphism, Resistance to infection, TIM-1",

author = "Mara Biasin and Manuela Sironi and Irma Saulle and Chiara Pontremoli and Micaela Garziano and Rachele Cagliani and Daria Trabattoni and {Lo Caputo}, Sergio and Francesca Vichi and Francesco Mazzotta and Diego Forni and Stefania Riva and Wbeimar Aguilar-Jimenez and Samandhy Cede{\~n}o and Jorge Sanchez and Christian Brander and Wildeman Zapata and Rugeles, {Maria Teresa} and Mario Clerici",

year = "2017",

month = jan,

day = "1",

doi = "10.1016/j.micinf.2016.09.005",

language = "English",

volume = "19",

pages = "69--74",

journal = "Microbes and Infection",

issn = "1286-4579",

publisher = "Elsevier Masson SAS",

number = "1",

}

Biasin, M, Sironi, M, Saulle, I, Pontremoli, C, Garziano, M, Cagliani, R, Trabattoni, D, Lo Caputo, S, Vichi, F, Mazzotta, F, Forni, D, Riva, S, Aguilar-Jimenez, W, Cedeño, S, Sanchez, J, Brander, C, Zapata, W, Rugeles, MT & Clerici, M 2017, 'A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection', Microbes and Infection, vol. 19, núm. 1, pàg. 69-74. https://doi.org/10.1016/j.micinf.2016.09.005

TY - JOUR

T1 - A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection

AU - Biasin, Mara

AU - Sironi, Manuela

AU - Saulle, Irma

AU - Pontremoli, Chiara

AU - Garziano, Micaela

AU - Cagliani, Rachele

AU - Trabattoni, Daria

AU - Lo Caputo, Sergio

AU - Vichi, Francesca

AU - Mazzotta, Francesco

AU - Forni, Diego

AU - Riva, Stefania

AU - Aguilar-Jimenez, Wbeimar

AU - Cedeño, Samandhy

AU - Sanchez, Jorge

AU - Brander, Christian

AU - Zapata, Wildeman

AU - Rugeles, Maria Teresa

AU - Clerici, Mario

PY - 2017/1/1

Y1 - 2017/1/1

N2 - © 2016 Institut Pasteur We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a p value of 0.005. In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.

AB - © 2016 Institut Pasteur We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a p value of 0.005. In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.

KW - HESN

KW - HIV

KW - Polymorphism

KW - Resistance to infection

KW - TIM-1

U2 - 10.1016/j.micinf.2016.09.005

DO - 10.1016/j.micinf.2016.09.005

M3 - Article

SN - 1286-4579

VL - 19

SP - 69

EP - 74

JO - Microbes and Infection

JF - Microbes and Infection

IS - 1

ER -

A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection

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SDG de les Nacions Unides

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