TY - JOUR
T1 - β-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus
AU - Salvador, Noelia
AU - Lasa, Íñigo
AU - Maiques, Elisa
AU - Úbeda, Carles
AU - Campoy, Susana
AU - Penadés, José R.
AU - Novick, Richard P.
AU - Barbé, Jordi
PY - 2006/4/1
Y1 - 2006/4/1
N2 - Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer of pathogenicity island-encoded virulence factors. Here we report that β-lactams induce a bona fide SOS response in S. aureus, characterized by the activation of the RecA and LexA proteins, the two master regulators of the SOS response. Moreover, we show that β-lactams are capable of triggering staphylococcal prophage induction in S. aureus lysogens. Consequently, and as previously described for SOS induction by commonly used fluoroquinolone antibiotics, β-lactam- mediated phage induction also resulted in replication and high-frequency transfer of the staphylococcal pathogenicity islands, showing that such antibiotics may have the unintended consequence of promoting the spread of bacterial virulence factors. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
AB - Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer of pathogenicity island-encoded virulence factors. Here we report that β-lactams induce a bona fide SOS response in S. aureus, characterized by the activation of the RecA and LexA proteins, the two master regulators of the SOS response. Moreover, we show that β-lactams are capable of triggering staphylococcal prophage induction in S. aureus lysogens. Consequently, and as previously described for SOS induction by commonly used fluoroquinolone antibiotics, β-lactam- mediated phage induction also resulted in replication and high-frequency transfer of the staphylococcal pathogenicity islands, showing that such antibiotics may have the unintended consequence of promoting the spread of bacterial virulence factors. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
UR - https://dialnet.unirioja.es/servlet/articulo?codigo=1982902
U2 - 10.1128/JB.188.7.2726-2729.2006
DO - 10.1128/JB.188.7.2726-2729.2006
M3 - Article
SN - 0021-9193
VL - 188
SP - 2726
EP - 2729
JO - Journal of Bacteriology
JF - Journal of Bacteriology
IS - 7
ER -