GENOMIC ANALYSIS OF FIBROLAMELLAR HEPATOCELLULAR CARCINOMA REVEALS A UNIQUE MOLECULAR PROFILE

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Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer usually developed in non-cirrhotic livers of children and young adults with unknown etiology. Treatment is limited to surgical intervention. To date, molecular pathogenesis of FLC has been poorly characterized. A cohort of FLCs was analyzed through SNP-array. GISTIC algorithm identified chromosomal aberrations. FLC tumors corresponding to 25 different patients. In all cases, tumor and corresponding non-tumor samples were frozen (-80°C) after hepatic resection at diagnosis. Comparative Genomic Hybridization analysis was done using Illumina HumanHap370CNV Genotyping BeadChip SNP array
Data disponible12 de febr. 2015
EditorArrayExpress

  • Unique genomic profile of fibrolamellar hepatocellular carcinoma

    Cornella, H., Alsinet, C., Sayols, S., Zhang, Z., Hao, K., Cabellos, L., Hoshida, Y., Villanueva, A., Thung, S., Ward, S. C., Rodriguez-Carunchio, L., Vila-Casadesús, M., Imbeaud, S., Lachenmayer, A., Quaglia, A., Nagorney, D. M., Minguez, B., Carrilho, F., Roberts, L. R. & Waxman, S. I 6 altres, Mazzaferro, V., Schwartz, M., Esteller, M., Heaton, N. D., Zucman-Rossi, J. & Llovet, J. M., 1 d’abr. 2015, In: GASTROENTEROLOGY. 148, 4, pàg. 806-818.e10

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